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      Date:   14 September, 2015

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Injectable Anaesthesia in the dog, cat, guinea pig and rabbit
Dr Sing Kong Yuen, BVMS (Glasgow), MRCVS
First recorded: 5 April, 2011
14 September, 2015
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Be Kind To Pets
Veterinary Education
Project 2010-0129

Injectable anaesthesia in the healthy dog and cat
in one syringe. Calculated dosage for healthy animals

Weight Domitor Ketamine
10kg  healthy 0.4 ml IV 0.5 ml IV
Dogs less than 5 years old, in good health
Domitor 5-40ug/kg = 0.005mg/kg-0.04mg/kg
Ketamine 2-5mg/kg
Heart-diseased dogs - Do not use domitor+ketamine
Old dog - Use less domitor

Injectable anaesthesia in the healthy dog and cat in one syringe. Calculated dosage for healthy animals

Weight Diazepam Ketamine
10kg healthy dog 0.8 ml* IV 0.5 ml IV
     
Diazepam 0.1-0.4 mg/kg. 
* is based on maximal dose
Ketamine 2-5mg/kg
Heart-diseased dogs - give 50% + isoflurane gas top up
Spay healthy dogs - give higher dose in the higher range. No need isoflurane gas top up. 
 
Weight Xylazine Ketamine
2-3 kg healthy cat 0.1ml 0.4 ml
3-4 kg healthy cat 0.15ml 0.6 ml
4-5 kg healthy cat 0.2ml 0.8ml
I find the above dosage IM effective and safe for spaying and neutering to be done in less than 20 minutes. Top up with isoflurane if necessary. I know of a vet who routinely use Reverzine to reverse the xylazine-induced sedation. It must be given by IV only.  

Rabbit & Guinea Pig.
Use Subcutaneous inj only in one syringe

Weight Domitor Ketamine
1kg  healthy 0.2 ml SC 0.1 ml SC
     
Domitor 0.02 -0.25 mg/kg
Ketamine 10 -15mg/kg
DETAILS:
Domitor 1mg/ml = 1,000ug/ml
Ketamine  100mg/ml
Diazepam 5mg/ml
Xylazine + Ketamine IM can also be used in rabbit anaesthesia.

CASE STUDIES OF 3 DOGS
USING DOMITOR + KETAMINE

Weight Domitor
Calculated
Ketamine
Calculated
Domitor Given Ketamine Given
10kg  healthy 0.4 ml IV 0.5 ml IV    
         
Case 1
Fox Terrier, 1 year,
9.3kg spay
0.37 ml IV 0.47 ml IV 0.2 ml IV 0.3 ml IV
Young, healthy Needs isoflurane maintenance as dosage is below calculated dose. No problems. When antisedan 0.2 ml IM is given, wakes up alert but limbs are rigid. Can't stand up till atropine 0.1 ml IV is given.
         
Case 2
Shih Tzu, F, 7 years,
8.1 kg
0.32 ml IV 0.41 ml IV 0.1 ml IV 0.4ml IV
Old age, be careful Needs isoflurane maintenance as dosage is below calculated dose. No problems. Dental scaling. When antisedan 0.1 ml IV is given, no cries. Just wakes up as if from a nap. 
Case 3
Maltese, F, 8 years
, 4.3 kg
0.17 ml IV 0.22 ml IV 0.1ml IV 0.2ml IV
Old age, be careful No need isoflurane gas as dosage is close to calculated dose. 6 teeth extracted. No problem. When antisedan 0.1 ml IV is given, cries in pain. Given tolfedine injection. Stops crying. 
Dosage for the two old dogs - shih tzu and maltese
IV anaesthesia  domitor-ketamine one syringe dogs toapayohvets singapore    
Fox Terrier, 1 year, Spayed. Rigid limbs after giving antisedan
to wake up the dog early
IV anaesthesia  domitor-ketamine one syringe dogs toapayohvets singapore Effect of ketamine after Antisedan is given. Fox terrier spay. toapayohvets  singapore Effect of ketamine after Atropine is given as limbs were rigid. Fox terrier spay. toapayohvets  singapore

In conclusion, domitor and ketamine are synergistic and their combined use will be safer if injectable anaesthetics are required and no isoflurane gas is available. For healthy dogs, use the calculated dosage given above.

For heart-diseased dogs, use diazepam + ketamine at 50% of calculated dose and give isoflurane gas top up. Do NOT use domitor + ketamine is heart-diseased dogs.

For dogs over 7 years, use 50% of calculated dose for healthy dogs and top up with isoflurane gas if necessary.

older syrian hamster large cystic mixed tumour below neck risky anaesthesia and surgery toapayohvets tpvets_logo.jpg (2726 bytes)

BE KIND TO HAMSTERS. Get their tumours removed when they are much smaller. More case studies, goto:  Hamsters

To make an appointment: e-mail judy@toapayohvets.com
tel: +65 9668-6469, 6254-3326

toapayohvets.com 
Be Kind To Pets
Veterinary Education
Project 2010-0129
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